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NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
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NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
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Journal Article
NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
2021
Overview
The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.
Publisher
MDPI AG,MDPI
Subject
/ Animals
/ Cardiovascular Diseases - etiology
/ Cardiovascular Diseases - metabolism
/ Cardiovascular Diseases - pathology
/ Cardiovascular System - metabolism
/ Cardiovascular System - pathology
/ Diabetes
/ Disease
/ DNA-Binding Proteins - metabolism
/ DNA-Binding Proteins - physiology
/ Heart
/ Humans
/ Ligands
/ Nerve Tissue Proteins - metabolism
/ Nerve Tissue Proteins - physiology
/ Pulmonary Arterial Hypertension
/ Receptors, Steroid - metabolism
/ Receptors, Steroid - physiology
/ Receptors, Thyroid Hormone - metabolism
/ Receptors, Thyroid Hormone - physiology
/ Review
