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Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

by Schiavoni, Ilaria , Adkins, Irena , Fedele, Giorgio , Sebo, Peter , Klimova, Nela

in Adenosine monophosphate / Adenylate cyclase / Adenylate Cyclase Toxin - immunology / Animals / Bacteria / Bordetella pertussis / CD11b antigen / Cyclic AMP / Cyclic AMP - chemistry / Dendritic cells / Dendritic Cells - immunology / Helper cells / Host-Pathogen Interactions / Humans / Immune response / Immune system / Immunity / Immunity, Cellular / Immunity, Mucosal / Immunoregulation / Innate immunity / intracellular pathways / Leukocytes (neutrophilic) / Lymphocytes / Lymphocytes T / Macrophages / Macrophages - immunology / Neutrophils / Neutrophils - immunology / Opsonophagocytosis / Pertussis / Phagocytes / Phagocytosis / Respiratory System - immunology / Respiratory System - microbiology / Respiratory tract / Review / Signal Transduction / Signaling / T-helper cells / T-Lymphocytes, Regulatory - immunology / Toxins / Whooping cough / Whooping Cough - immunology

2017

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Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

by Schiavoni, Ilaria , Adkins, Irena , Fedele, Giorgio , Sebo, Peter , Klimova, Nela

2017

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Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

by Schiavoni, Ilaria , Adkins, Irena , Fedele, Giorgio , Sebo, Peter , Klimova, Nela

2017

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Journal Article

Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

Schiavoni, Ilaria,

Adkins, Irena,

Fedele, Giorgio,

Sebo, Peter,

Klimova, Nela

2017

Overview

Adenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key players of the innate immune system that provide a first line of defense against invading pathogens. Recent findings revealed the capacity of B. pertussis CyaA to intoxicate DC with high concentrations of 3′,5′-cyclic adenosine monophosphate (cAMP), which ultimately skews the host immune response towards the expansion of Th17 cells and regulatory T cells. CyaA-induced cAMP signaling swiftly incapacitates opsonophagocytosis, oxidative burst and NO-mediated killing of bacteria by neutrophils and macrophages. The subversion of host immune responses by CyaA after delivery into DC, macrophages and neutrophils is the subject of this review.

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Publisher

MDPI AG,MDPI

Subject

Adenosine monophosphate

/ Adenylate cyclase

/ Adenylate Cyclase Toxin - immunology

/ Animals

/ Bacteria

/ Bordetella pertussis

/ CD11b antigen