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Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell Carcinoma Diagnosis

by SHIMIZU, DAI , NAGAO, TORU , MIYABE, SATORU , GOTO, MITSUO , SHIMOZATO, KAZUO , HASHIMOTO, KENGO , HASEGAWA, SHOGO , OH-IWA, ICHIRO , UEDA, SEI , NOMOTO, SHUJI

in Biomarkers / Biomarkers, Tumor - genetics / Breast cancer / Calcium-Binding Proteins / Gene expression / Head and Neck Neoplasms - diagnosis / Head and Neck Neoplasms - genetics / Hospitals / Humans / Liver cancer / Medical prognosis / Mouth Neoplasms - diagnosis / Mouth Neoplasms - genetics / Receptors, Cell Surface / Saliva / Squamous cell carcinoma / Squamous Cell Carcinoma of Head and Neck - diagnosis / Squamous Cell Carcinoma of Head and Neck - genetics

2020

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Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell Carcinoma Diagnosis

by SHIMIZU, DAI , NAGAO, TORU , MIYABE, SATORU , GOTO, MITSUO , SHIMOZATO, KAZUO , HASHIMOTO, KENGO , HASEGAWA, SHOGO , OH-IWA, ICHIRO , UEDA, SEI , NOMOTO, SHUJI

2020

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Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell Carcinoma Diagnosis

by SHIMIZU, DAI , NAGAO, TORU , MIYABE, SATORU , GOTO, MITSUO , SHIMOZATO, KAZUO , HASHIMOTO, KENGO , HASEGAWA, SHOGO , OH-IWA, ICHIRO , UEDA, SEI , NOMOTO, SHUJI

2020

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Journal Article

Salivary NUS1 and RCN1 Levels as Biomarkers for Oral Squamous Cell Carcinoma Diagnosis

SHIMIZU, DAI,

NAGAO, TORU,

MIYABE, SATORU,

GOTO, MITSUO,

SHIMOZATO, KAZUO,

HASHIMOTO, KENGO,

HASEGAWA, SHOGO,

OH-IWA, ICHIRO,

UEDA, SEI,

NOMOTO, SHUJI

2020

Overview

Oral cancer may become advanced because of delay in diagnosis. In order to promote oral cancer screening, simple and highly reliable screening methods that can be implemented at general dental clinics are required. Herein we investigated differential salivary gene expression between oral squamous cell carcinoma (OSCC) patients and healthy volunteers (HV) to identify new biomarkers for OSCC detection. Candidate genes were selected by microarrays, nuclear undecaprenyl pyrophosphate synthase 1 (NUS1) and reticulocalbin 1 (RCN1) were selected for further investigation. We used real-time quantitative reverse transcription PCR (qRT-PCR) to determine NUS1 and RCN1 expression levels in saliva and tissues. qRT-PCR analysis of clinical samples revealed that OSCC patients had significantly higher expression of salivary NUS1 and RCN1 than HV. A combination of NUS1 and RCN1 accurately distinguished patients from controls, and this combination can be implemented as a screening test for OSCC.

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Publisher

International Institute of Anticancer Research

Subject

Biomarkers

/ Biomarkers, Tumor - genetics

/ Breast cancer

/ Calcium-Binding Proteins

/ Gene expression

/ Head and Neck Neoplasms - diagnosis

/ Head and Neck Neoplasms - genetics