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Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin

by Novichkova, M. D. , Tatarskiy, V. V. , Zhdanov, D. D. , Shtil, A. A. , Kalinina, E. V. , Volodina, Yu. L. , Hasan, A. A. Sh , Petrova, А. S. , Nurmuradov, N. K. , Chernov, N. N.

in 1-Phosphatidylinositol 3-kinase / Adenocarcinoma / AKT protein / Antioxidants / Apoptosis / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer cells / Cell Biology / Cell cycle / Cell death / Chemotherapy / Cisplatin / Curcumin / Drug resistance / Enzymes / Gene expression / Genes / Genetic transcription / Internal Medicine / Kinases / Laboratory Medicine / Ovarian cancer / Pathology / Signal transduction / Superoxide dismutase / TOR protein / Tumors

2022

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Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin

by Novichkova, M. D. , Tatarskiy, V. V. , Zhdanov, D. D. , Shtil, A. A. , Kalinina, E. V. , Volodina, Yu. L. , Hasan, A. A. Sh , Petrova, А. S. , Nurmuradov, N. K. , Chernov, N. N.

2022

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Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin

by Novichkova, M. D. , Tatarskiy, V. V. , Zhdanov, D. D. , Shtil, A. A. , Kalinina, E. V. , Volodina, Yu. L. , Hasan, A. A. Sh , Petrova, А. S. , Nurmuradov, N. K. , Chernov, N. N.

2022

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Journal Article

Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin

Novichkova, M. D.,

Tatarskiy, V. V.,

Zhdanov, D. D.,

Shtil, A. A.,

Kalinina, E. V.,

Volodina, Yu. L.,

Hasan, A. A. Sh,

Petrova, А. S.,

Nurmuradov, N. K.,

Chernov, N. N.

2022

Overview

The effect of curcumin on the resistance of SKOV-3 human ovarian adenocarcinoma cells to cisplatin was studied. It was found that curcumin induced “reversal” of cancer cells resistance, which was associated with suppression of the expression of genes encoding the key antioxidant enzymes ( SOD1 , SOD2 , CAT , GPX1 , and HO-1 ) and transcription factor Nrf2 and a decrease in the expression of genes encoding kinases of the PI3K/Akt/mTOR signaling pathway. The obtained results confirm the role of redox-dependent regulation in the “reversal” of cancer cells resistance to cisplatin.

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Publisher

Springer US,Springer,Springer Nature B.V

Subject

1-Phosphatidylinositol 3-kinase

/ Biomedical and Life Sciences

/ Biomedicine