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Aspiration therapy for obesity; a safe and effective treatment
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Journal Article
Aspiration therapy for obesity; a safe and effective treatment
2016
Overview
Background
This study evaluated the efficacy and safety of the novel AspireAssist® Aspiration Therapy System for treatment of obesity, and its effect on patient’s quality of life.
Methods
A prospective observational study with 25 obese subjects, mean age 48 years (range 33–65), was performed. A custom gastrostomy tube (A-tube, Aspire Bariatrics) was percutaneously inserted during a gastroscopy performed under conscious sedation. Drainage and irrigation of the stomach were performed 3 times daily, 20 min after each meal, for 1–2 years. Efficient aspiration required thorough chewing of ingested food. Treatment included a cognitive behavioral weight loss program.
Results
Mean body mass index (BMI) at inclusion was 39.8 kg/m
2
(range 35–49). After 1 year mean (SD) BMI was 32.1 kg/m
2
(5.4),
p
< 0.01, and excess weight loss was 54.4% (28.8),
p
< 0.01. Quality of life, as measured with EQ-5D, improved from 0.73 (0.27) to 0.88 (0.13),
p
< 0.01. After 2 years BMI was 31.0 kg/m
2
(5.1),
p
< 0.01, and excess weight loss was 61.5% (28.5),
p
< 0.01. There were no serious adverse events or electrolyte disorders. Compliance was 80% after 1 year and 60% after 2 years.
Conclusions
Aspiration therapy is an efficient and safe treatment for obesity, and weight reduction improves quality of life. Excess weight was approximately halved in a year, with weight stability if treatment was continued.
Trial registration
Trial Register
ISRCTN 49958132
. Retrospectively registered 28/02/2014.
Publisher
BioMed Central,BioMed Central Ltd
