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Biomarkers in anal cancer: from biological understanding to stratified treatment
by
Sebag-Montefiore, David
, Jones, Christopher M
, Gilbert, Duncan C
, Goh, Vicky
in
631/67/1059/485
/ 631/67/1059/99
/ 631/67/1504/1299
/ Anus Neoplasms - diagnosis
/ Anus Neoplasms - etiology
/ Anus Neoplasms - therapy
/ Biology
/ Biomarkers
/ Biomarkers, Tumor - physiology
/ Biomedical and Life Sciences
/ Biomedicine
/ Cancer Research
/ Cancer therapies
/ Carcinoma, Squamous Cell - diagnosis
/ Carcinoma, Squamous Cell - etiology
/ Carcinoma, Squamous Cell - therapy
/ Cell Transformation, Viral
/ Chemoradiotherapy
/ Chemotherapy
/ Drug Resistance
/ Epidemiology
/ Human papillomavirus
/ Humans
/ Medical prognosis
/ Medical research
/ mini-review
/ Minireview
/ Molecular Medicine
/ Oncology
/ Papillomaviridae - physiology
/ Radiation therapy
/ Response rates
/ Surgery
/ Toxicity
/ Tumors
/ Viruses
2017
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Biomarkers in anal cancer: from biological understanding to stratified treatment
by
Sebag-Montefiore, David
, Jones, Christopher M
, Gilbert, Duncan C
, Goh, Vicky
in
631/67/1059/485
/ 631/67/1059/99
/ 631/67/1504/1299
/ Anus Neoplasms - diagnosis
/ Anus Neoplasms - etiology
/ Anus Neoplasms - therapy
/ Biology
/ Biomarkers
/ Biomarkers, Tumor - physiology
/ Biomedical and Life Sciences
/ Biomedicine
/ Cancer Research
/ Cancer therapies
/ Carcinoma, Squamous Cell - diagnosis
/ Carcinoma, Squamous Cell - etiology
/ Carcinoma, Squamous Cell - therapy
/ Cell Transformation, Viral
/ Chemoradiotherapy
/ Chemotherapy
/ Drug Resistance
/ Epidemiology
/ Human papillomavirus
/ Humans
/ Medical prognosis
/ Medical research
/ mini-review
/ Minireview
/ Molecular Medicine
/ Oncology
/ Papillomaviridae - physiology
/ Radiation therapy
/ Response rates
/ Surgery
/ Toxicity
/ Tumors
/ Viruses
2017
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Do you wish to request the book?
Biomarkers in anal cancer: from biological understanding to stratified treatment
by
Sebag-Montefiore, David
, Jones, Christopher M
, Gilbert, Duncan C
, Goh, Vicky
in
631/67/1059/485
/ 631/67/1059/99
/ 631/67/1504/1299
/ Anus Neoplasms - diagnosis
/ Anus Neoplasms - etiology
/ Anus Neoplasms - therapy
/ Biology
/ Biomarkers
/ Biomarkers, Tumor - physiology
/ Biomedical and Life Sciences
/ Biomedicine
/ Cancer Research
/ Cancer therapies
/ Carcinoma, Squamous Cell - diagnosis
/ Carcinoma, Squamous Cell - etiology
/ Carcinoma, Squamous Cell - therapy
/ Cell Transformation, Viral
/ Chemoradiotherapy
/ Chemotherapy
/ Drug Resistance
/ Epidemiology
/ Human papillomavirus
/ Humans
/ Medical prognosis
/ Medical research
/ mini-review
/ Minireview
/ Molecular Medicine
/ Oncology
/ Papillomaviridae - physiology
/ Radiation therapy
/ Response rates
/ Surgery
/ Toxicity
/ Tumors
/ Viruses
2017
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Biomarkers in anal cancer: from biological understanding to stratified treatment
Journal Article
Biomarkers in anal cancer: from biological understanding to stratified treatment
2017
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Overview
Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with oncogenic subtypes of human papilloma virus and this plays a significant role in their sensitivity to treatment. However, not all tumours are cured with CRT and there remain opportunities to improve outcomes in terms of oncological control and also reducing late toxicities. Understanding the biology of ASCC promises to allow a more personalised approach to treatment, with the development and validation of a range of biomarkers and associated techniques that are the focus of this review.
Publisher
Nature Publishing Group UK,Nature Publishing Group
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