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Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants

by Lee, Bonggi , Ryu, BoMi , Jung, Won-Kyo , Tennakoon, Pipuni , Choi, Il-Whan , Yi, Myunggi , Kim, Hyun-Woo , Kim, Tae-Hee , Je, Jae-Young , Kim, Jae-Il , Kim, Chang , Kim, Se-Chang , Park, Won , Kim, Young-Mog , Chandika, Pathum , Kang, Hyun

in Aging / Aging (natural) / anticoagulant / Anticoagulants / Biological activity / Bleeding / Blood clots / blood coagulation / Blood platelets / Blood vessels / Cardiovascular diseases / chemically modified macromolecules / Coagulation / Defects / Defence mechanisms / Disease prevention / Drug dosages / Fibrin / Fibrinogen / Flora / Hemorrhage / Heparin / Macromolecules / Marine animals / marine anticoagulant macromolecules / Marine biology / Marine chemistry / Marine flora / Marine plants / marine sources / Mortality / Pathogenesis / Pharmacokinetics / Proteins / Review / Thromboembolism / Thrombosis / Veins & arteries

2022

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2022

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2022

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Journal Article

Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants

Lee, Bonggi,

Ryu, BoMi,

Jung, Won-Kyo,

Tennakoon, Pipuni,

Choi, Il-Whan,

Yi, Myunggi,

Kim, Hyun-Woo,

Kim, Tae-Hee,

Je, Jae-Young,

Kim, Jae-Il,

Kim, Chang,

Kim, Se-Chang,

Park, Won,

Kim, Young-Mog,

Chandika, Pathum,

Kang, Hyun

2022

Overview

Coagulation is a potential defense mechanism that involves activating a series of zymogens to convert soluble fibrinogen to insoluble fibrin clots to prevent bleeding and hemorrhagic complications. To prevent the extra formation and diffusion of clots, the counterbalance inhibitory mechanism is activated at levels of the coagulation pathway. Contrariwise, this system can evade normal control due to either inherited or acquired defects or aging which leads to unusual clots formation. The abnormal formations and deposition of excess fibrin trigger serious arterial and cardiovascular diseases. Although heparin and heparin-based anticoagulants are a widely prescribed class of anticoagulants, the clinical use of heparin has limitations due to the unpredictable anticoagulation, risk of bleeding, and other complications. Hence, significant interest has been established over the years to investigate alternative therapeutic anticoagulants from natural sources, especially from marine sources with good safety and potency due to their unique chemical structure and biological activity. This review summarizes the coagulation cascade and potential macromolecular anticoagulants derived from marine flora and fauna.

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Publisher

MDPI AG,MDPI

Subject

/ Biological activity

/ Bleeding

/ Blood clots