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Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

by Antoniac, Aurora , Antoniac, Iulian , Robu, Alina , Bodog, Alin Dănuț , Bița, Ana-Iulia , Corneschi, Iuliana , Băcilă, Ciprian Ionuț , Gheorghiță, Daniela , Moldovan, Horațiu , Grosu, Elena

in Antibacterial agents / Antifungal agents / Biocompatible Materials - pharmacology / Biocompatible Materials - therapeutic use / Biological products / Blood / Calcium phosphates / Carbon / Chitosan - pharmacology / Chitosan - therapeutic use / Clay / Health aspects / Hemorrhage / Hemorrhage - drug therapy / Hemorrhage - prevention & control / Hemostasis / Hemostatics - pharmacology / Hemostatics - therapeutic use / Homeopathy / Humans / Materia medica and therapeutics / Medical research / Morbidity / Mortality / Nanoparticles / Polyethylene terephthalate / Review / Romania / Silica / Surgeons / Surgery / Therapeutics / Trauma / Wound healing

2023

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Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

2023

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Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

2023

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Journal Article

Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

Antoniac, Aurora,

Antoniac, Iulian,

Robu, Alina,

Bodog, Alin Dănuț,

Bița, Ana-Iulia,

Corneschi, Iuliana,

Băcilă, Ciprian Ionuț,

Gheorghiță, Daniela,

Moldovan, Horațiu,

Grosu, Elena

2023

Overview

Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding that can become life-threatening if not properly managed. Moreover, uncontrolled bleeding can complicate surgical interventions, altering the outcome of surgical procedures. Therefore, to reduce the risk of complications and decrease the risk of morbidity and mortality associated with hemorrhage, it is necessary to use an effective hemostatic agent that ensures the immediate control of bleeding. In recent years, there have been increasingly rapid advances in developing a novel generation of biomaterials with hemostatic properties. Nowadays, a wide array of topical hemostatic agents is available, including chitosan-based biomaterials that have shown outstanding properties such as antibacterial, antifungal, hemostatic, and analgesic activity in addition to their biocompatibility, biodegradability, and wound-healing effects. This review provides an analysis of chitosan-based hemostatic biomaterials and discusses the progress made in their performance, mechanism of action, efficacy, cost, and safety in recent years.

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Publisher

MDPI AG,MDPI

Subject

Antibacterial agents

/ Antifungal agents

/ Biocompatible Materials - pharmacology

/ Biocompatible Materials - therapeutic use

/ Biological products

/ Blood

/ Calcium phosphates