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The DREAM complex represses growth in response to DNA damage in Arabidopsis

by Bögre, László , Lang, Lucas , Schnittger, Arp , Magyar, Zoltán , Takatsuka, Hirotomo , Heese, Maren , Eeckhout, Dominique , Ito, Masaki , Pettkó-Szandtner, Aladár , Zaki, Ahmad , Nomoto, Yuji , De Jaeger, Geert , Dorokhov, Stefan , Tunçay Elbaşı, Hasibe

in Animals / Arabidopsis / Cell culture / Cell cycle / Cell death / Cell proliferation / DNA damage / DNA methylation / DNA repair / Environmental conditions / Kinases / Mutants / Proteins / Retinoblastoma / Signal transduction / Transcription factors / Tumor suppressor genes

2021

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The DREAM complex represses growth in response to DNA damage in Arabidopsis

2021

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2021

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Journal Article

The DREAM complex represses growth in response to DNA damage in Arabidopsis

Bögre, László,

Lang, Lucas,

Schnittger, Arp,

Magyar, Zoltán,

Takatsuka, Hirotomo,

Heese, Maren,

Eeckhout, Dominique,

Ito, Masaki,

Pettkó-Szandtner, Aladár,

Zaki, Ahmad,

Nomoto, Yuji,

De Jaeger, Geert,

Dorokhov, Stefan,

Tunçay Elbaşı, Hasibe

2021

Overview

The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth and cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog of the mammalian tumor suppressor gene retinoblastoma, plays a key role in the DNA damage response in plants, we unravel here the network of RBR1 interactors under DNA stress conditions. This led to the identification of homologs of every DREAM component in Arabidopsis, including previously not recognized homologs of LIN52. Interestingly, we also discovered NAC044, a mediator of DNA damage response in plants and close homolog of the major DNA damage regulator SOG1, to directly interact with RBR1 and the DREAM component LIN37B. Consistently, not only mutants in NAC044 but also the double mutant of the two LIN37 homologs and mutants for the DREAM component E2FB showed reduced sensitivities to DNA-damaging conditions. Our work indicates the existence of multiple DREAM complexes that work in conjunction with NAC044 to mediate growth arrest after DNA damage.

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Life Science Alliance,Life Science Alliance LLC

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