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Nucleic Acid Testing to Detect HBV Infection in Blood Donors
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Journal Article
Nucleic Acid Testing to Detect HBV Infection in Blood Donors
2011
Overview
In this study involving 3.7 million blood donors, nucleic acid testing identified 9 donors with HBV infection who were not identified by routine serologic testing. The single triplex assay also identified 2 donors with HIV and 15 with HCV.
The transfusion of blood containing hepatitis B surface antigen (HBsAg) is associated with post-transfusion infection with hepatitis B virus (HBV). Blood that is free of HBsAg but has high-titer antibodies against hepatitis B core antigen (anti-HBc) in the absence of antibodies against hepatitis B surface antigen (anti-HBs) can also transmit HBV infection.
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,
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In 1986, screening for anti-HBc was implemented in the United States to reduce HBV transmission and as a surrogate marker for non-A, non-B hepatitis (i.e., hepatitis C virus [HCV]).
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,
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However, a small proportion of donors with anti-HBc in the absence of HBsAg have circulating HBV DNA . . .
Publisher
Massachusetts Medical Society
Subject
Biological and medical sciences
/ Disease Transmission, Infectious
/ Genotype
/ Hepatitis B Antibodies - blood
/ Hepatitis B Core Antigens - blood
/ Hepatitis B Surface Antigens - blood
/ Hepatitis B Surface Antigens - immunology
/ Hepatitis B virus - genetics
/ Hepatitis B virus - isolation & purification
/ HIV - isolation & purification
/ Humans
/ Nucleic Acid Amplification Techniques
