Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice

by Deguchi Yusuke , Marília Oliveira de Almeida , Ryuzo Kozuka , Jairo Kenupp Bastos , Akio Watanabe , Andresa Aparecida Berreta , Takayuki Yonezawa , Je-Tae Woo , Caroline Arruda

in Adipocytes / Antidiabetics / baccharin / Diabetes / Gene expression / Glucose / Glycerol / Homeostasis / Hyperglycemia / Insulin resistance / Investigations / Ligands / Lipids / Metabolism / PPARγ / propolis / Tumor necrosis factor-TNF

2021

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice

by Deguchi Yusuke , Marília Oliveira de Almeida , Ryuzo Kozuka , Jairo Kenupp Bastos , Akio Watanabe , Andresa Aparecida Berreta , Takayuki Yonezawa , Je-Tae Woo , Caroline Arruda

2021

Confirm

Do you wish to request the book?

Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice

by Deguchi Yusuke , Marília Oliveira de Almeida , Ryuzo Kozuka , Jairo Kenupp Bastos , Akio Watanabe , Andresa Aparecida Berreta , Takayuki Yonezawa , Je-Tae Woo , Caroline Arruda

2021

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice

Deguchi Yusuke,

Marília Oliveira de Almeida,

Ryuzo Kozuka,

Jairo Kenupp Bastos,

Akio Watanabe,

Andresa Aparecida Berreta,

Takayuki Yonezawa,

Je-Tae Woo,

Caroline Arruda

2021

Overview

Propolis is a honeybee product with various biological activities, including antidiabetic effects. We previously reported that artepillin C, a prenylated cinnamic acid derivative isolated from Brazilian green propolis, acts as a peroxisome proliferator-activated receptor γ (PPARγ) ligand and promotes adipocyte differentiation. In this study, we examined the effect of baccharin, another major component of Brazilian green propolis, on adipocyte differentiation. The treatment of mouse 3T3-L1 preadipocytes with baccharin resulted in increased lipid accumulation, cellular triglyceride levels, glycerol-3-phosphate dehydrogenase activity, and glucose uptake. The mRNA expression levels of PPARγ and its target genes were also increased by baccharin treatment. Furthermore, baccharin enhanced PPARγ-dependent luciferase activity, suggesting that baccharin promotes adipocyte differentiation via PPARγ activation. In diabetic ob/ob mice, intraperitoneal administration of 50 mg/kg baccharin significantly improved blood glucose levels. Our results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus.

Share this book

Add to My Shelf

Publisher

MDPI AG,MDPI

Subject

/ Glucose