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Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms
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Journal Article
Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms
2005
Overview
A population-based case–control study of lymphomas in England collected height and weight details from 699 non-Hodgkin's lymphoma (NHL) cases and 914 controls. Obesity, defined as a body mass index (BMI) over 30 kg m
−2
at five years before diagnosis,, was associated with an increased risk of NHL (OR=1.5, 95% CI 1.1–2.1). The excess was most pronounced for diffuse large B-cell lymphoma (OR=1.9, 95% CI 1.3–2.8). Genetic variants in the leptin (
LEP
19G>A,
LEP
−2548G>A) and leptin receptor genes (
LEPR
223Q>R), previously shown to modulate NHL risk, as well as a polymorphism in the energy regulatory gene adiponectin (
APM1
276G>T), were investigated. Findings varied with leptin genotype, the risks being decreased with LEP 19AA (OR=0.7, 95% CI 0.5–1.0) and increased with LEP −2548GA (OR=1.3, 95% CI 1.0–1.7) and −2548AA (OR=1.4, 95% CI 1.0–1.9), particularly for follicular lymphoma. These genetic findings, which were independent of BMI, were stronger for men than women.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Energy
/ Genes
/ Hematologic and hematopoietic diseases
/ Humans
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Lymphoma
/ Lymphoma, Non-Hodgkin - complications
/ Lymphoma, Non-Hodgkin - genetics
/ Lymphoma, Non-Hodgkin - metabolism
/ Obesity
/ Oncology
/ Receptors, Cell Surface - genetics
/ Tumors
