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A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer

by van Seijen, Maartje , Mukhtar, Rita A. , Mackintosh, Lorna , Pusztai, Lajos , Sonke, Gabe S. , Earl, Helena , de Croze, Diane , Esserman, Laura J. , Dunn, Janet , Martín, Miguel , Schwensen, Kelsey , López-Tarruella, Sara , Wesseling, Jelle , Hayward, Larry , Steenbruggen, Tessa G. , Cameron, David , del Monte-Millán, Maria , Fan, Fang , van der Noordaa, Marieke , Laé, Marick , Provenzano, Elena , DeMichele, Angela M. , Bartlett, John M. S. , Godwin, Andrew K. , J van ’t Veer, Laura , Boughey, Judy C. , Caldas, Carlos , Sammut, Stephen-John , Graham, Ashley , Abraham, Jean E. , Hoskin, Tanya , Valero, Vicente , Hamy, Anne-Sophie , Osdoit, Marie , Fraser Symmans, W. , Yau, Christina , Sharma, Priyanka , Goetz, Matthew P. , Hiller, Louise , Cole, Kimberly , Edge, Stephen B. , Hall, Peter , Gottipati, Soumya , Kim, Mi-Ok , Reyal, Fabien , Thomas, Jeremy S.

in 692/4028/67/1347 / 692/53/2422 / Biomedical and Life Sciences / Biomedicine / Breast cancer / Cancer Research / Cancer therapies / Cell Biology / Chemotherapy / Clinical trials / Histology / Human Genetics / Lymphatic system / Medical prognosis / Medical research / Oncology / Patients / Review boards / Standard of care

2025

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A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer

2025

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2025

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Journal Article

A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer

van Seijen, Maartje,

Mukhtar, Rita A.,

Mackintosh, Lorna,

Pusztai, Lajos,

Sonke, Gabe S.,

Earl, Helena,

de Croze, Diane,

Esserman, Laura J.,

Dunn, Janet,

Martín, Miguel,

Schwensen, Kelsey,

López-Tarruella, Sara,

Wesseling, Jelle,

Hayward, Larry,

Steenbruggen, Tessa G.,

Cameron, David,

del Monte-Millán, Maria,

Fan, Fang,

van der Noordaa, Marieke,

Laé, Marick,

Provenzano, Elena,

DeMichele, Angela M.,

Bartlett, John M. S.,

Godwin, Andrew K.,

J van ’t Veer, Laura,

Boughey, Judy C.,

Caldas, Carlos,

Sammut, Stephen-John,

Graham, Ashley,

Abraham, Jean E.,

Hoskin, Tanya,

Valero, Vicente,

Hamy, Anne-Sophie,

Osdoit, Marie,

Fraser Symmans, W.,

Yau, Christina,

Sharma, Priyanka,

Goetz, Matthew P.,

Hiller, Louise,

Cole, Kimberly,

Edge, Stephen B.,

Hall, Peter,

Gottipati, Soumya,

Kim, Mi-Ok,

Reyal, Fabien,

Thomas, Jeremy S.

2025

Overview

Residual Cancer Burden (RCB) after neoadjuvant chemotherapy (NAC) is validated to predict event-free survival (EFS) in breast cancer but has not been studied for invasive lobular carcinoma (ILC). We studied patient-level data from a pooled cohort across 12 institutions. Associations between RCB index, class, and EFS were assessed in ILC and non-ILC with mixed effect Cox models and multivariable analyses. Recursive partitioning was used in an exploratory model to stratify prognosis by RCB components. Of 5106 patients, the diagnosis was ILC in 216 and non-ILC in 4890. Increased RCB index was associated with worse EFS in both ILC and non-ILC ( p = 0.002 and p < 0.001, respectively) and remained prognostic when stratified by receptor subtype and adjusted for age, grade, T category, and nodal status. Recursive partitioning demonstrated residual invasive cancer cellularity as most prognostic in ILC. These results underscore the utility of RCB for evaluating NAC response in those with ILC.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

692/4028/67/1347

/ 692/53/2422

/ Biomedical and Life Sciences