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Journal Article
Basal bodies in Xenopus
2016
Overview
Xenopus
has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies in
Xenopus
revealed the fine structures of
Xenopus
basal bodies and their accessory structures. Subsequent investigations using multiciliated cells in the
Xenopus
epidermis have further revealed many important features regarding the transcriptional regulation of basal body amplification as well as the regulation of basal body/cilia polarity. Future basal body research using
Xenopus
is expected to focus on the application of modern genome editing techniques (CRISPR/TALEN) to characterize the components of basal body proteins and their molecular functions.
Publisher
BioMed Central,BioMed Central Ltd
