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Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy

by Angrisani, Antonio , Della Corte, Carminia Maria , Guida, Cesare , Facchini, Sergio , Fasano, Morena , Nardone, Valerio , Cappabianca, Salvatore , Caterino, Marianna , Caliendo, Valentina , Reginelli, Alfonso , D’Onofrio, Ida , Belfiore, Maria Paola , Pirozzi, Mario

in Age / Cancer therapies / Chemotherapy / Comorbidity / Decision making / Geriatrics / Head and neck carcinoma / Malignancy / Medical prognosis / Neuropsychology / Older people / Patients / Physiology / Population / Quality of life / Radiation therapy / Review / Squamous cell carcinoma

2022

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Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy

2022

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Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy

2022

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Journal Article

Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy

Angrisani, Antonio,

Della Corte, Carminia Maria,

Guida, Cesare,

Facchini, Sergio,

Fasano, Morena,

Nardone, Valerio,

Cappabianca, Salvatore,

Caterino, Marianna,

Caliendo, Valentina,

Reginelli, Alfonso,

D’Onofrio, Ida,

Belfiore, Maria Paola,

Pirozzi, Mario

2022

Overview

Head and neck squamous cell carcinomas (HNSCC) constitute the sixth most common malignancy worldwide, with approximately 25–40% of the diagnosed patients older than 70 years. HNSCC patients are often frail and frequently have multiple comorbidities due to their unhealthy lifestyle, and evidence suggests that older patients may receive less aggressive and suboptimal treatment than younger patients with the same disease status. The aim of this review is to depict and summarize the evidence regarding the different strategies that can be used in the clinical management of elderly HNSCC patients. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used. This paper contains a narrative report and a critical discussion of clinical approaches in the context of elderly HNSCC.

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Publisher

MDPI AG,MDPI

Subject

/ Head and neck carcinoma