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The biogenesis and emerging roles of circular RNAs
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The biogenesis and emerging roles of circular RNAs
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Journal Article
The biogenesis and emerging roles of circular RNAs
2016
Overview
Circular RNAs (circRNAs) are produced from precursor RNA back-splicing. Recent findings reveal the complexity of the biogenesis of circRNAs and their cell type-specific expression. They also show that circRNAs can shape eukaryotic transcriptomes by sequestering microRNAs and by regulating transcription and interfering with splicing.
Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels, recent findings have shed new light on their cell type-specific and tissue-specific expression and on the regulation of their biogenesis. Furthermore, the data indicate that circRNAs shape gene expression by titrating microRNAs, regulating transcription and interfering with splicing, thus effectively expanding the diversity and complexity of eukaryotic transcriptomes.
