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Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

by Elias, W. Jeff , Chang, Wei-Chieh , Guridi, Jorge , Halpern, Casey H. , Dalvi, Arif , Fishman, Paul S. , McDannold, Nathan , Cosgrove, Rees , Lozano, Andres M. , Baltuch, Gordon , Constantinescu, Marius , Kaplitt, Michael , Eisenberg, Howard M. , del Alamo, Marta , Ghanouni, Pejman , Fasano, Alfonso , Chang, Jin Woo , Khemani, Pravin , Schlesinger, Ilana , Krishna, Vibhor , Eleopra, Roberto , Gwinn, Ryder , Martinez Fernandez, Raul

in Ablation / Adverse events / Clinical trials / Dyskinesia / Dyskinesias - etiology / Dyskinesias - surgery / FDA approval / Gait / Globus pallidus / Globus Pallidus - surgery / High-Intensity Focused Ultrasound Ablation / Humans / Magnetic resonance imaging / Movement disorders / Neurodegenerative diseases / Neurology / Neurosurgery / Pallidotomy / Parkinson Disease / Parkinson Disease - complications / Parkinson Disease - surgery / Parkinson's disease / Surgery / Surgery General / Treatment Outcome / Ultrasonic imaging / Ultrasound

2023

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Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

2023

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Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

2023

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Journal Article

Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

Elias, W. Jeff,

Chang, Wei-Chieh,

Guridi, Jorge,

Halpern, Casey H.,

Dalvi, Arif,

Fishman, Paul S.,

McDannold, Nathan,

Cosgrove, Rees,

Lozano, Andres M.,

Baltuch, Gordon,

Constantinescu, Marius,

Kaplitt, Michael,

Eisenberg, Howard M.,

del Alamo, Marta,

Ghanouni, Pejman,

Fasano, Alfonso,

Chang, Jin Woo,

Khemani, Pravin,

Schlesinger, Ilana,

Krishna, Vibhor,

Eleopra, Roberto,

Gwinn, Ryder,

Martinez Fernandez, Raul

2023

Overview

In patients with Parkinson’s disease, focused ultrasound ablation of the globus pallidus internus reduced motor impairment and dyskinesias at 3 months. Adverse events included dysarthria, gait disturbance, and loss of taste.

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Publisher

Massachusetts Medical Society

Subject

/ Dyskinesias - etiology

/ Dyskinesias - surgery

/ FDA approval