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MicroRNAs in cell proliferation, cell death, and tumorigenesis
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MicroRNAs in cell proliferation, cell death, and tumorigenesis
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Journal Article
MicroRNAs in cell proliferation, cell death, and tumorigenesis
2006
Overview
MicroRNAs (miRNAs) are a recently discovered class of approximately 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.
Publisher
Nature Publishing Group
