Journal Article

Red Cell Distribution Width-to-Platelet Ratio and Other Hematological Markers as Early Predictors of Bronchopulmonary Dysplasia in Preterm Infants

Arcagok, Baran Cengiz, Kandemir, Ibrahim

2025

Overview

Background/Objectives: Bronchopulmonary dysplasia (BPD) frequently affects preterm infants and is associated with lasting morbidity. Early prediction remains challenging. The present study investigated whether hematological inflammatory markers—platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and red cell distribution width-to-platelet ratio (RPR)—can predict the development of BPD in preterm neonates. Methods: We performed a retrospective cohort study involving 100 infants born at less than 32 weeks’ gestation. Complete blood count (CBC) parameters were collected at birth, 72 h, 1 week, and 2 weeks of life. Associations between PLR, RDW, RPR, and BPD development were analyzed. Multivariate regression and receiver operating characteristic (ROC) curve analyses were carried out to evaluate the predictive performance of the markers. Results: Forty-nine percent of infants developed BPD. Those with BPD had significantly higher RDW, PLR, and RPR values, and lower lymphocyte and platelet counts at various time points. Gestational age, respiratory distress syndrome, and hematological indices independently predicted BPD. ROC analysis showed that RDW ≥ 67.2 and PLR ≥ 98.13 at 72 h, and RPR ≥ 0.3 at 7 and 14 days had good predictive performance. A combined scoring system, including clinical and hematological markers, achieved high sensitivity and specificity. Conclusions: Hematological inflammatory markers, especially RPR, PLR, and RDW, derived from routine CBC tests may serve as accessible, cost-effective tools for early BPD risk stratification in preterm infants. Additional studies are needed to confirm these results and better define their relevance in clinical practice.

• Publisher: MDPI AG
• Subject: Blood / Blood platelets / Bronchopulmonary dysplasia / Congenital diseases / Gestational age / Hematology / Infants (Premature) / Inflammation / inflammatory biomarkers / Lung diseases / Lymphocytes / Medical colleges / Medical examination / Medical research / Medicine, Experimental / Newborn babies / Oxidative stress / Pneumonia / Postpartum period / Premature babies / preterm infants platelet-to-lymphocyte ratio / RDW-to-platelet ratio / Respiratory distress syndrome / Sepsis / Surfactants / Ventilators