Journal Article

A Novel Mesoporous Biomaterial for Treating Dentin Hypersensitivity

LIN H.-P., LIU H.-C., CHIANG Y.-C., LEE B.-S., KANG S.-H., LIN F.-H., LIN C.-P., CHEN H.-J.

2010

Overview

An ideal material has yet to be discovered that can completely treat dentin hypersensitivity; however, calcium phosphate precipitation has exhibited potential value for the treatment of dentin hypersensitivity by the occlusion of dentinal tubules. We hypothesized that a novel mesoporous silica biomaterial (nano CaO@mesoporous silica, NCMS) containing nano-sized calcium oxide particles mixed with 30% phosphoric acid can efficiently occlude dentinal tubules and significantly reduce dentin permeability, even with the presence of pulpal pressure. This highly supersaturated Ca2+-and HPO4 2−ion-containing NCMS paste was brushed onto dentin surfaces, and the ions diffused deeply into the dentinal tubules and formed a CaHPO4·2H2O precipitation with a depth of 100 μm. The results of the dentin permeability tests showed that the novel mesoporous material exhibited a significant reduction in dentin permeability (p < 0.05), even under simulated pulpal pressure, as compared with our previously developed material, DP-bioglass, and a commercial desensitizing material, Seal & Protect®.

• Publisher: SAGE Publications,International Association for Dental Research,SAGE PUBLICATIONS, INC
• Subject: Acids / Analysis of Variance / bioactive glass / Biocompatible Materials - chemistry / Biocompatible Materials - therapeutic use / Biological and medical sciences / Biomaterials / Calcium Compounds - chemistry / Calcium Compounds - therapeutic use / Calcium oxide / Calcium permeability / Calcium phosphates / CaO / Chemical precipitation / Dentin / Dentin - drug effects / Dentin - ultrastructure / dentin hypersensitivity / dentin permeability / Dentin Sensitivity - drug therapy / Drug Carriers - chemistry / Drug Carriers - therapeutic use / Facial bones, jaws, teeth, parodontium: diseases, semeiology / Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics / Humans / Hypersensitivity / Materials Testing / Maxillofacial surgery. Dental surgery. Orthodontics / Medical sciences / mesoporous silica / Nanoparticles - therapeutic use / Nanoparticles - ultrastructure / Non tumoral diseases / Occlusion / Otorhinolaryngology. Stomatology / Oxides - chemistry / Oxides - therapeutic use / Particle size / Permeability / Phosphoric acid / Pressure / Resin Cements - therapeutic use / Rheology / Silica / Silicon Dioxide - chemistry / Silicon Dioxide - therapeutic use / Sodium / Surfactants / Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases / Tubules