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Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

by Mursalin, M. H. , Callegan, Michelle C. , Muhammad, Fauziyya , Lee, Darren J. , Avalos, Priscilla N. , Ma, Jian-Xing

in Angiogenesis inhibitors / Animals / autoimmune disease / Autoimmune Diseases - genetics / Autoimmune Diseases - immunology / Autoimmune Diseases - metabolism / Autoimmune Diseases - prevention & control / autoimmune uveitis / Autoimmunity / Cell activation / Cloning / Diabetes / Diabetic retinopathy / Disease Models, Animal / Euthanasia / Experimental autoimmune uveitis / Experimental autoimmune uveoretinitis / Flow cytometry / Immunity / Immunization / Immunology / kallistatin / Laboratories / Lymphocyte Activation / Lymphocytes / Lymphocytes T / Mice, Inbred C57BL / Mice, Transgenic / Ostomy / Proteins / Serine proteinase inhibitors / Serpins - genetics / Serpins - metabolism / Spleen / Spleen - immunology / Spleen - metabolism / T cells / T-Lymphocytes - immunology / T-Lymphocytes - metabolism / Uvea - immunology / Uvea - metabolism / Uvea - pathology / Uveitis / Uveitis - genetics / Uveitis - immunology / Uveitis - metabolism / Uveitis - prevention & control

2020

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Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

by Mursalin, M. H. , Callegan, Michelle C. , Muhammad, Fauziyya , Lee, Darren J. , Avalos, Priscilla N. , Ma, Jian-Xing

2020

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Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

by Mursalin, M. H. , Callegan, Michelle C. , Muhammad, Fauziyya , Lee, Darren J. , Avalos, Priscilla N. , Ma, Jian-Xing

2020

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Journal Article

Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

Mursalin, M. H.,

Callegan, Michelle C.,

Muhammad, Fauziyya,

Lee, Darren J.,

Avalos, Priscilla N.,

Ma, Jian-Xing

2020

Overview

Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive.

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Publisher

Frontiers Media SA,Frontiers Media S.A

Subject

Angiogenesis inhibitors

/ Animals

/ autoimmune disease

/ Autoimmune Diseases - genetics

/ Autoimmune Diseases - immunology

/ Autoimmune Diseases - metabolism

/ Autoimmune Diseases - prevention & control