Asset Details
Do you wish to reserve the book?
Toward a structural understanding of Clostridium difficile toxins A and B
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Toward a structural understanding of Clostridium difficile toxins A and B
Do you wish to request the book?
Toward a structural understanding of Clostridium difficile toxins A and B
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Toward a structural understanding of Clostridium difficile toxins A and B
2012
Overview
Clostridium difficile is a toxin-producing bacterium that is a frequent cause of hospital-acquired and antibiotic-associated diarrhea. The incidence, severity, and costs associated with C. difficile associated disease are substantial and increasing, making C. difficile a significant public health concern. The two primary toxins, TcdA and TcdB, disrupt host cell function by inactivating small GTPases that regulate the actin cytoskeleton. This review will discuss the role of these two toxins in pathogenesis and the structural and molecular mechanisms by which they intoxicate cells. A focus will be placed on recent publications highlighting mechanistic similarities and differences between TcdA, TcdB, and different TcdB variants.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Animals
/ Bacteria
/ Bacterial Proteins - chemistry
/ Bacterial Proteins - metabolism
/ Bacterial Toxins - chemistry
/ Bacterial Toxins - metabolism
/ Cholera
/ Clostridium difficile - chemistry
/ Clostridium difficile - pathogenicity
/ Diarrhea
/ Humans
/ Monomeric GTP-Binding Proteins - antagonists & inhibitors
/ Toxin A
/ Toxins
