Journal Article

The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review

Plebanski, Magdalena, Azid, Nor Azrini, Chen, Xin, Ahmad, Suhana, Mohamud, Rohimah, Lim, JitKang, Boer, Jennifer C.

2018

Overview

Tumor necrosis factor-alpha (TNF) is a pleiotropic cytokine, which is thought to play a major role in the pathogenesis of inflammatory diseases, including allergy. TNF is produced at the early stage of allergen sensitization, and then continues to promote the inflammation cascade in the effector phase of allergic reactions. Consequently, anti-TNF treatment has been proposed as a potential therapeutic option. However, recent studies reveal anti-intuitive effects of TNF in the activation and proliferative expansion of immunosuppressive Tregs, tolerogenic DCs and MDSCs. This immunosuppressive effect of TNF is mediated by TNFR2, which is preferentially expressed by immunosuppressive cells. These findings redefine the role of TNF in allergic reaction, and suggest that targeting TNF-TNFR2 interaction itself may represent a novel strategy in the treatment of allergy.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Allergens / Allergies / allergy / Apoptosis / Asthma / Autoimmune diseases / Cytokines / Dermatitis / Disease / Food allergies / Hay fever / Homeostasis / Hypersensitivity / Immunology / Immunosuppression / Inflammation / Inflammatory diseases / Kinases / Lymphocytes / Pathogenesis / Polymorphism / Proteins / regulatory T cells / Rhinitis / TNF / TNFR2 / tolerogenic dendritic cells / Tumor necrosis factor / Tumor necrosis factor-TNF