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Adoptive T Cell Therapy for Epstein–Barr Virus Complications in Patients With Primary Immunodeficiency Disorders
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Adoptive T Cell Therapy for Epstein–Barr Virus Complications in Patients With Primary Immunodeficiency Disorders
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Journal Article
Adoptive T Cell Therapy for Epstein–Barr Virus Complications in Patients With Primary Immunodeficiency Disorders
2018
Overview
Patients with primary immunodeficiency disorders (PID) have an increased risk from acute and chronic Epstein-Barr Virus (EBV) viral infections and EBV-associated malignancies. Hematopoietic stem cell transplantation (HSCT) is a curative strategy for many patients with PID, but EBV-related complications are common in the immediate post-transplant period due to delayed reconstitution of T cell immunity. Adoptive T cell therapy with EBV-specific T cells is a promising therapeutic strategy for patients with PID both before and after HSCT. Here we review the methods used to manufacture EBV-specific T cells, the clinical outcomes, and the ongoing challenges for future development of the strategy.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Antigens
/ Antigens, Viral - immunology
/ Epstein-Barr Virus Infections - complications
/ Epstein-Barr Virus Infections - immunology
/ Epstein-Barr Virus Infections - virology
/ hematopoietic stem cell transplantation
/ Hematopoietic Stem Cell Transplantation - methods
/ Herpesvirus 4, Human - immunology
/ Herpesvirus 4, Human - physiology
/ Humans
/ Immunologic Deficiency Syndromes - complications
/ Immunologic Deficiency Syndromes - immunology
/ Immunologic Deficiency Syndromes - therapy
/ Peptides
/ primary immunodeficiency disorders
