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Commentary: Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation
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Commentary: Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation
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Journal Article
Commentary: Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation
2020
Overview
To address this problem, we applied our model of receptor-mediated transmembrane signaling, the Signaling Chain HOmoOLigomerization (SCHOOL), first published in 2004 (9,10) to rationally design TREM-1-specific inhibitory peptide sequence(s) (SCHOOL peptides/sequences) that employ a novel, ligand-independent mechanism of TREM-1 inhibition. In this regard, we thought it proper to remind the readership of Frontiers in Immunology of our pioneering study of 2014 that demonstrated the therapeutic effect of a first-in-class ligand-independent TREM-1 inhibitory peptide sequence GLLSKSLVF (mouse TREM-1-specific SCHOOL peptide) in experimental sepsis [(11);Table 1]. (2019)10:2314.10.3389/fimmu.2019.0231431632399 17.SigalovAB.Targeting intramembrane protein-protein interactions: novel therapeutic strategy of millions years old.Adv Protein Chem Struct Biol.
Publisher
Frontiers Media SA,Frontiers Media S.A
