Asset Details
Do you wish to reserve the book?
CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients
Do you wish to request the book?
CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients
2021
Overview
Cytotoxic CD8 + T-cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The aim of this study was to investigate the role of CD107a (LAMP-1) on cytotoxic CD8 + T-cells in SLE-patients in particular with lupus nephritis. Peripheral blood of SLE-patients ( n = 31) and healthy controls ( n = 21) was analyzed for the expression of CD314 and CD107a by flow cytometry. Kidney biopsies of lupus nephritis patients were investigated for the presence of CD8 + and C107a + cells by immunohistochemistry and immunofluorescence staining. The percentages of CD107a + on CD8 + T-cells were significantly decreased in SLE-patients as compared to healthy controls (40.2 ± 18.5% vs. 47.9 ± 15.0%, p = 0.02). This was even more significant in SLE-patients with inactive disease. There was a significant correlation between the percentages of CD107a + CD8 + T-cells and SLEDAI. The evaluation of lupus nephritis biopsies showed a significant number of CD107a + CD8 + T-cells mainly located in the peritubular infiltrates. The intrarenal expression of CD107a + was significantly correlated with proteinuria. These results demonstrate that CD8 + T-cells of patients with systemic lupus erythematosus have an altered expression of CD107a which seems to be associated with disease activity. The proof of intrarenal CD107a + CD8 + suggests a role in the pathogenesis of lupus nephritis.
