Journal Article

Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function

Linterman, Michelle A., Watt, Alan P., Bignon, Alexandre

2017

Overview

Treatments to limit T cell activation are essential for managing autoimmune and inflammatory disorders. The B subunit of heat-labile enterotoxin (EtxB) is known to ameliorate inflammatory disease but the mechanism by which this is mediated is not well understood. Here, we show that following intranasal administration, EtxB acts on two key cellular regulators of T cell activation: regulatory T cells and dendritic cells (DCs). EtxB enhances the proliferation of lung regulatory T cells and doubles their suppressive function, likely through an increase in expression of the Treg effector molecule CTLA-4. EtxB supports the generation of interleukin-10-producing DCs that are unable to activate T cells. These data show, for the first time, that mucosal EtxB treatment limits T cells activation by acting jointly on two distinct types of immune cells.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Adjuvants / Antigens / Cell activation / Cell proliferation / CTLA-4 protein / Dendritic cells / E coli / Enterotoxin B / Escherichia coli / EtxB / Flow cytometry / Genotype & phenotype / Heat / Heat-labile enterotoxin / Immune system / Immunology / immunomodulation / Immunoregulation / Inflammatory diseases / Interleukin 10 / Intranasal administration / Kinases / lung / Lymphocytes / Lymphocytes T / Proteins / regulatory T cells / Toxins