Journal Article

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis

Cao, Faqi, Xue, Hang, Zhang, Peng, Liu, Guohui, Chen, Lang, Zhou, Wu, Xv, Yan, Lin, Ze, Yan, Chenchen, Endo, Yori, Hu, Yiqiang, Hu, Liangcong

2022

Overview

Diabetic wounds remain a great challenge for clinicians due to the multiple bacterial infections and oxidative damage. Exosomes, as an appealing nanodrug delivery system, have been widely applied in the treatment of diabetic wounds. Endovascular cells are important component cells of the vascular wall. Herein, we investigated the effects of HUCMSCs and HUC-Exos (exosomes secreted by HUCMSCs) on diabetic wound healing. In this study, HUVECs were coincubated with HUCMSCs, and HUC-Exos were utilized for in vitro and in vivo experiments to verify their roles in the regulation of diabetic wound healing. Our results demonstrated that HUCMSCs have the ability to regulate oxidative stress injuries of endothelial cells through exosomes and accelerate diabetic cutaneous wound healing in vitro . The present study suggests that HUC-Exos accelerate diabetic cutaneous wound healing, providing a promising therapeutic strategy for chronic diabetic wound repair.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Angiogenesis / Bioengineering and Biotechnology / Cardiovascular system / Diabetes / Diabetes mellitus / Drug resistance / Endothelial cells / exosome / Exosomes / Foot diseases / Glucose / Hyperglycemia / Mesenchymal stem cells / Oxidative stress / Physiology / Reactive oxygen species / Signal transduction / stem cells / Umbilical cord / Wound healing