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Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
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Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
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Journal Article
Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration
2017
Overview
The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the inhibitory A1R has traditionally been ascribed to have a neuroprotective function in various brain insults. This review provides a summary of the emerging role of prolonged A1R signaling and its potential cross-talk with A2AR in the cellular basis for increased neurotoxicity in neurodegenerative disorders. This A1R signaling enhances A2AR-mediated neurodegeneration, and provides a platform for future development of neuroprotective agents in stroke, Parkinson’s disease and epilepsy.
Publisher
MDPI AG,MDPI
Subject
/ adenosine receptor cross-talk
/ Animals
/ Humans
/ Neurodegenerative Diseases - drug therapy
/ Neurodegenerative Diseases - metabolism
/ Neuroprotective Agents - pharmacology
/ Purinergic Agonists - pharmacology
/ Purinergic Antagonists - pharmacology
/ Receptor, Adenosine A1 - physiology
/ Receptor, Adenosine A2A - physiology
/ Review
