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New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

by Liu, Leticia H. B. , dos Santos, Roney V. , Stanisic, Danijela , Costa, Amanda F. , Durán, Nelson , Tasic, Ljubica

in Aging / Aging - drug effects / Aging - physiology / anti-ageing / antioxidant / Antioxidants / Chelating Agents - pharmacology / Chromatography / Citrus fruits / Collagenases - metabolism / Cosmetics / Emulsions - chemistry / Enzymes / Flavonoids / Fourier transforms / hesperidin / Hesperidin - chemistry / Hesperidin - isolation & purification / Hesperidin - pharmacology / Hesperidin - toxicity / Humans / Kinases / Lipids / Male / Microemulsions / nanocrystals / Nanoparticles - chemistry / Nanoparticles - ultrastructure / new-clean process extraction / NMR / Nuclear magnetic resonance / Particle Size / Skin / Skin Cream - pharmacology / Solvents / Spectrometry, Fluorescence / Spectroscopy, Fourier Transform Infrared / Spectrum analysis / Static Electricity / Thermodynamics

2020

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New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

by Liu, Leticia H. B. , dos Santos, Roney V. , Stanisic, Danijela , Costa, Amanda F. , Durán, Nelson , Tasic, Ljubica

2020

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New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

by Liu, Leticia H. B. , dos Santos, Roney V. , Stanisic, Danijela , Costa, Amanda F. , Durán, Nelson , Tasic, Ljubica

2020

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Journal Article

New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

Liu, Leticia H. B.,

dos Santos, Roney V.,

Stanisic, Danijela,

Costa, Amanda F.,

Durán, Nelson,

Tasic, Ljubica

2020

Overview

Hesperidin, a secondary orange (Citrus sinensis) metabolite, was extracted from orange bagasse. No organic solvents or additional energy consumption were used in the clean and sustainable process. Hesperidin purity was approximately 98% and had a yield of 1%. Hesperidin is a known supplement due to antioxidant, chelating, and anti-ageing properties. Herein, hesperidin application to eliminate dark eye circles, which are sensitive and thin skin regions, was studied. In addition, the proposed method for its aqueous extraction was especially important for human consumption. Further, the most effective methods for hesperidin nanonization were explored, after which the nanoemulsions were incorporated into a cream formulation that was formulated for a tropical climate. Silky cream formulations (oil in water) were tested in vitro on artificial 3D skin from cultured cells extracted from skin residues after plastic surgery. The proposed in vitro assay avoided tests of the different formulations in human volunteers and animals. It was shown that one of the nanonized hesperidin formulations was the most skin-friendly and might be used in cosmetics.

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Publisher

MDPI AG,MDPI

Subject

Aging

/ Aging - drug effects

/ Chelating Agents - pharmacology