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Emerging Threat of Multidrug Resistant Pathogens From Neonatal Sepsis
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Emerging Threat of Multidrug Resistant Pathogens From Neonatal Sepsis
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Journal Article
Emerging Threat of Multidrug Resistant Pathogens From Neonatal Sepsis
2021
Overview
Multidrug-resistant (MDR) pathogens are responsible for a substantial burden of morbidity and mortality from neonatal sepsis; however, data on these sepsis-related pathogens among hospitalized neonates in China are not well characterized. In this study, a total of 240 strains were isolated from four Women and Children’s hospitals in Southwest China between 2014 and 2019. Of these included pathogens, 104 (43.33%) were gram-positive bacteria, 129 (53.75%) were gram-negative bacteria, and 7 (2.92%) were fungi. Escherichia coli ( E. coli , 34.01%) and Klebsiella pneumoniae ( K. pneumoniae , 15.35%) were the main pathogen of neonate bacteremia. ST167 were the most prevalent STs in E. coli and ST11 in K. pneumoniae. Our study found that E. coli (62.71%) was the predominate pathogen of early-onset sepsis, among which 64.86% were MDR. Late-onset sepsis was mainly caused by K. pneumoniae (28.31%) and E. coli (24.78%), with showing that 78.33% of these pathogens were MDR. Notably, the prevalence of EO/LO pathogens were quite different from Indian and south of China. Moreover, we found that bla CTX-M (42.06%) was most dominant resistant genes with about a third isolates (31.09%) were positive for bla CTX-M-15 . All the carbapenem-resistant K. pneumoniae were positive for NDM-1. Moreover, late-onset sepsis and antibiotic exposure were significantly associated with MDR infection. Emerging multi-resistant pathogens of sepsis posts a serious threat to neonatal outcomes and emphasizes an urgent need to control their further spread.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Bacteria
/ Cellular and Infection Microbiology
/ Drug Resistance, Multiple, Bacterial
/ E coli
/ early-onset bloodstream infections
/ Enzymes
/ Humans
/ Klebsiella pneumoniae - genetics
/ late-onset bloodstream infections
/ Neonatal Sepsis - epidemiology
/ Neonates
/ Sepsis
