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Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola
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Journal Article
Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola
2018
Overview
Two new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] (1) and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (2), were isolated from the myxobacterium Labilithrix luteola (DSM 27648T). Additionally, four metabolites 3, 4, 5 and 6 already known from other sources were obtained. Their structures were elucidated from high resolution electrospray ionisation mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy data and their relative configuration was assigned based on nuclear Overhauser effect (NOE) and vicinal 1H-NMR coupling data. The compounds where tested for biological activities; labindoles A (1) and B (2) exhibited significant activity against Hepatitis C Virus, 9H-carbazole (3), 3-chloro-9H-carbazole (4) and 4-hydroxymethyl-quinoline (5) showed antifungal activities. Moreover, compound 3 had weak to moderate antibacterial activities, while labindoles A (1) and B (2) were devoid of significant antifungal and antibacterial effects.
Publisher
MDPI AG,MDPI
Subject
Anti-Infective Agents - chemistry
/ Anti-Infective Agents - pharmacology
/ Antiviral Agents - chemistry
/ Antiviral Agents - pharmacology
/ Biological Products - chemistry
/ Biological Products - pharmacology
/ HCV
/ Heterocyclic Compounds - chemistry
/ Heterocyclic Compounds - pharmacology
/ Magnetic Resonance Spectroscopy
/ NMR
