Asset Details
Do you wish to reserve the book?
Nanog and transcriptional networks in embryonic stem cell pluripotency
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Nanog and transcriptional networks in embryonic stem cell pluripotency
Do you wish to request the book?
Nanog and transcriptional networks in embryonic stem cell pluripotency
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Nanog and transcriptional networks in embryonic stem cell pluripotency
2007
Overview
Several extrinsic signals such as LIF, BMP and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the “pluripotent genes.” A unique homeobox transcription factor, Nanog, is one of the key downstream effectors of these signals. Elevated level of Nanog can maintain the mouse ES cell self-renewal independent of LIF and enable human ES cell growth without feeder cells. In addition to the external signal pathways, intrinsic transcription factors such as FoxD3, P53 and Oct4 are also involved in regulating the expression of Nanog. Functionally, Nanog works together with other key pluripotent factors such as Oct4 and Sox2 to control a set of target genes that have important functions in ES cell pluripotency. These key factors form a regulatory network to support or limit each other's expression level, which maintains the properties of ES cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - physiology
/ Embryonic Stem Cells - cytology
/ Embryonic Stem Cells - metabolism
/ Embryonic Stem Cells - physiology
/ Gene Expression Regulation, Developmental - physiology
/ Homeodomain Proteins - genetics
/ Homeodomain Proteins - physiology
/ Humans
/ Pluripotent Stem Cells - cytology
/ Pluripotent Stem Cells - metabolism
/ Pluripotent Stem Cells - physiology
/ review
We currently cannot retrieve any items related to this title. Kindly check back at a later time.