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HLA-B Polymorphism in Japanese HIV-1-Infected Long-Term Surviving Hemophiliacs
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Journal Article
HLA-B Polymorphism in Japanese HIV-1-Infected Long-Term Surviving Hemophiliacs
2005
Overview
Approximately 30% of patients with hemophilia in Japan were infected with human immunodeficiency
virus (HIV) in early 1980s through contaminated blood products. In 1995, a cohort of HIVinfected,
asymptomatic patients with hemophilia was set up for follow-up study. Although the patients
met the criteria for long-term non-progressor (LTNP) at the entry to the cohort, some of them
later developed lymphopenia during five more years of observation. We collected blood samples
from 80 long-term survivors; 42 of them did not require antiviral therapy, but the rest were under
treatment. Analysis of HLA-B genotype revealed that carriers of known HIV-resistant alleles such
as HLA-B*5701, B*5801, and alleles of B27 antigenic group were not increased in frequency, but
that HLA-B*1507 was increased in the cohort (6.25% vs. 1.03%, OR = 6.40,
p
= 0.039). We also
observed the decrease in carriers of HLA-B*5401 (3.75% vs. 14.95%, OR = 0.22,
p
= 0.016). HLAB*
5401 is a relatively common allele in East Asian populations and belongs to the same B22 antigenic
group as B55 and B56 which were reported to associate with rapid progression. Our data indicated
that HLA class I is one of the host factors involved in the retardation of HIV disease
progression as also reported in the previous studies; however, the alleles associated with this resistance
were not the same because of divergent host genetic background.
Publisher
Mary Ann Liebert, Inc,SAGE Publications
