Asset Details
Do you wish to reserve the book?
Plasma proteomics and incident coronary heart disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Plasma proteomics and incident coronary heart disease
Do you wish to request the book?
Plasma proteomics and incident coronary heart disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Plasma proteomics and incident coronary heart disease
2026
Overview
Background
Systematic profiling of plasma proteins in population studies offers a complementary approach to discovery of novel risk factors and may provide new insights into the causes of coronary heart disease.
Methods
To explore relationships between the circulating proteome and coronary heart disease (CHD), we evaluated associations of 4780 plasma proteins with incident CHD in the Cardiovascular Health Study (CHS, N=2856, 575 CHD events) and replicated significant associations in the Atherosclerosis Risk in Communities Study (ARIC, N = 10456; 1375 events).
Results
We find that 11 proteins significantly associate with incident CHD after adjusting for risk factors; and eight significantly replicated in ARIC. Several proteins correlate with carotid intimal medial thickness and CHD associations are attenuated in participants without subclinical atherosclerosis. Macrophage metalloelastase (MMP12) is the strongest observed association (Hazard Ratio, 1.31; 95% Confidence Interval, 1.19-1.44). Mendelian randomization (MR) identifies a causal relationship between higher MMP12 and lower CHD (Odds Ratio, OR 0.94) and ischemic stroke (OR 0.90) risk, while reverse MR found that genetic propensity to CHD increased MMP12. Taken together, multivariable MR confirms a direct protective effect of higher
plasma
MMP12 on CHD risk and a
genetic
effect of atherosclerosis and CHD on elevating MMP12.
Conclusions
Proteomic analyses reveal associations with incident CHD and genomic evidence suggests that therapeutic MMP12 inhibition may confer adverse cardiovascular effects.
Plain Language Summary
Measuring many protein levels in the blood may provide new insights into the causes of heart disease (CHD). We evaluated thousands of plasma proteins in a study of older adults to determine whether any predicted risk of heart attacks or heart-related deaths and confirmed the findings in a second study. Eleven proteins showed evidence of association with CHD; often with stronger effects among those with pre-existing atherosclerosis. The strongest finding was for macrophage metalloelastase (MMP12), an endopeptidase expressed in vascular tissue and atherosclerotic plaque with roles in tissue repair, vascular remodeling, and reduction of inflammation. Our findings point to a complex role for this protein in response to underlying heart disease risk factors.
Huber et al. measure 4,780 plasma proteins in the Cardiovascular Health Study to examine the association with incident coronary heart disease. They identify 11 proteins using genomic analyses and show the complexity of MMP12 in response to atherosclerosis and development of heart disease.
