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Assessment circulating micro-RNA-192 in Egyptian patients with non-viral liver cirrhosis and hepatocellular carcinoma

by Soliman, Ayman S. , Gaber, Safy S. , Abujamai, Jakleen Z. , Damanhory, Ahmed A. , Elagali, Abdallah Mohammed , Huzien, Alaa H. , Abdelaziz, Mohamed Abdelaleim , Sakr, Hader I. , Ibrahim, Ahmed A.

in Alpha fetoprotein / And microRNA‑192 / Cancer Research / Enzymes / Hepatic cirrhosis / Hepatocellular carcinoma / Hospitals / Internal Medicine / Liver cancer / Liver cirrhosis / Liver diseases / Medical prognosis / Medicine / Medicine & Public Health / MicroRNAs / Molecular Medicine / Oncology / Patients / Radiotherapy / Regression analysis / Surgical Oncology

2026

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Assessment circulating micro-RNA-192 in Egyptian patients with non-viral liver cirrhosis and hepatocellular carcinoma

by Soliman, Ayman S. , Gaber, Safy S. , Abujamai, Jakleen Z. , Damanhory, Ahmed A. , Elagali, Abdallah Mohammed , Huzien, Alaa H. , Abdelaziz, Mohamed Abdelaleim , Sakr, Hader I. , Ibrahim, Ahmed A.

2026

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Assessment circulating micro-RNA-192 in Egyptian patients with non-viral liver cirrhosis and hepatocellular carcinoma

by Soliman, Ayman S. , Gaber, Safy S. , Abujamai, Jakleen Z. , Damanhory, Ahmed A. , Elagali, Abdallah Mohammed , Huzien, Alaa H. , Abdelaziz, Mohamed Abdelaleim , Sakr, Hader I. , Ibrahim, Ahmed A.

2026

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Journal Article

Assessment circulating micro-RNA-192 in Egyptian patients with non-viral liver cirrhosis and hepatocellular carcinoma

Soliman, Ayman S.,

Gaber, Safy S.,

Abujamai, Jakleen Z.,

Damanhory, Ahmed A.,

Elagali, Abdallah Mohammed,

Huzien, Alaa H.,

Abdelaziz, Mohamed Abdelaleim,

Sakr, Hader I.,

Ibrahim, Ahmed A.

2026

Overview

Background It is challenging to diagnose hepatic cirrhosis and hepatocellular carcinoma (HCC) at an early stage since non-invasive markers are not specific and do not identify the early stage. Objective Serum microRNA-192 could represent an early and critical pathogenetic factor in different liver diseases. Methods 92 participants were allocated into four equal groups ( n = 23): control, compensated liver cirrhosis, decompensated cirrhosis, and HCC groups. Results Decompensated cirrhosis and HCC showed significantly elevated Serum Alanine aminotransferase, aspartate aminotransferase, bilirubin, alpha-fetoprotein, and microRNA-192. Conclusion Serum microRNA-192 can predict decompensated liver cirrhosis and HCC with high sensitivity and specificity.

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Publisher

Springer US,Springer Nature B.V,Springer

Subject

/ Enzymes

/ Hepatocellular carcinoma

/ Hospitals