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Potential therapeutic uses of BDNF in neurological and psychiatric disorders
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Potential therapeutic uses of BDNF in neurological and psychiatric disorders
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Journal Article
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
2011
Overview
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease.
Publisher
Nature Publishing Group
Subject
/ Alzheimer Disease - drug therapy
/ Amyotrophic Lateral Sclerosis - drug therapy
/ Animals
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - administration & dosage
/ Brain-Derived Neurotrophic Factor - genetics
/ Brain-Derived Neurotrophic Factor - physiology
/ Brain-Derived Neurotrophic Factor - therapeutic use
/ Humans
/ Huntington Disease - drug therapy
/ Mental Disorders - drug therapy
/ Metabolic Diseases - drug therapy
/ Nervous System Diseases - drug therapy
/ Parkinson Disease - drug therapy
