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RT-QuIC for detection of prodromal α-synucleinopathies
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RT-QuIC for detection of prodromal α-synucleinopathies
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Journal Article
RT-QuIC for detection of prodromal α-synucleinopathies
2021
Overview
The concept of self-propagating proteins as a common causative feature in neurodegenerative diseases has led to the development of in-vitro misfolded protein amplification systems, such as protein misfolding cyclic amplification (PMCA) and real-time quaking-induced conversion (RT-QuIC) assays. The method is becoming increasingly important as a potential diagnostic tool in the field of neurodegenerative diseases.1–3 In The Lancet Neurology, Alex Iranzo and colleagues4 report the use of RT-QuIC to investigate α-synuclein in the CSF of patients with isolated rapid-eye-movement sleep behaviour disorder (IRBD), which can be part of the prodromal stage of α-synucleinopathies. The seeding activity of misfolded α-synuclein has previously been studied in people with the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies using brain tissue, CSF, submandibular gland tissues, olfactory mucosa samples, and skin biopsies.5–8 Some evidence is available that the seeding activity and specific aggregation kinetics of α-synuclein might be a function of the strain of α-synuclein that formed the initial pathogenic seed or the type of α-synucleinopathy.9,10 To address clinical needs for a reliable biomarker of α-synucleinopathies, these studies have been done with samples from living patients at various disease stages or brain tissue from autopsies.
Publisher
Elsevier Ltd,Elsevier Limited
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