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Wearable-sensor based walking and non-walking measures as progression markers in early to mid-stage Parkinson’s disease
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Wearable-sensor based walking and non-walking measures as progression markers in early to mid-stage Parkinson’s disease
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Journal Article
Wearable-sensor based walking and non-walking measures as progression markers in early to mid-stage Parkinson’s disease
2026
Overview
Digital measures of walking and sedentariness may objectively quantify Parkinson’s disease (PD) progression. We analyzed longitudinal wearable-sensor data to evaluate the sensitivity and specificity of digital walking and non-walking measures in ambulatory people with PD. We selected 26 individual and 6 composite measures with sufficient sensitivity and test-retest reliability in a development dataset (
N
= 171). Twenty measures showed significant within-participant changes, and 7 showed larger 2-year effect-size than gold-standard clinical measures in people with early-stage PD (
N
= 101, mean number of years since diagnosis [YSD], 2.2). Significant changes in non-walking and composite measures were detectable as early as 10 months. Twelve measures showed greater change in people with more advanced PD (
N
= 67; mean YSD 6.5) compared to matched non-PD individuals (
N
= 171). Sensitivity and specificity results indicate that measures capturing walking and especially non-walking behaviors hold promise as PD progression markers in early to mid-stage PD.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
