Asset Details
Do you wish to reserve the book?
Functional role of UNC13D in immune diseases and its therapeutic applications
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Functional role of UNC13D in immune diseases and its therapeutic applications
Do you wish to request the book?
Functional role of UNC13D in immune diseases and its therapeutic applications
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Functional role of UNC13D in immune diseases and its therapeutic applications
2024
Overview
UNC13 family (also known as Munc13) proteins are evolutionarily conserved proteins involved in the rapid and regulated secretion of vesicles, including synaptic vesicles and cytotoxic granules. Fast and regulated secretion at the neuronal and immunological synapses requires multiple steps, from the biogenesis of vesicles to membrane fusion, and a complex array of proteins for each step. Defects at these steps can lead to various genetic disorders. Recent studies have shown multiple roles of UNC13D in the secretion of cytotoxic granules by immune cells. Here, the molecular structure and detailed roles of UNC13D in the biogenesis, tethering, and priming of cytotoxic vesicles and in endoplasmic reticulum are summarized. Moreover, its association with immune diseases, including familial hemophagocytic lymphohistiocytosis type 3, macrophage activation syndrome, juvenile idiopathic arthritis, and autoimmune lymphoproliferative syndrome, is reviewed. Finally, the therapeutic application of CRISPR/Cas9-based gene therapy for genetic diseases is introduced.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ CRISPR
/ FHL3
/ Humans
/ Immune System Diseases - genetics
/ Immune System Diseases - immunology
/ Immune System Diseases - therapy
/ Membrane Proteins - genetics
/ Membrane Proteins - immunology
/ Membrane Proteins - metabolism
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - immunology
/ Nerve Tissue Proteins - metabolism
/ Proteins
/ UNC13D
