Asset Details
Do you wish to reserve the book?
Oncological effect of palliative transurethral resection of the prostate in patients with advanced prostate cancer: a propensity score matching study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Oncological effect of palliative transurethral resection of the prostate in patients with advanced prostate cancer: a propensity score matching study
Do you wish to request the book?
Oncological effect of palliative transurethral resection of the prostate in patients with advanced prostate cancer: a propensity score matching study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Oncological effect of palliative transurethral resection of the prostate in patients with advanced prostate cancer: a propensity score matching study
2018
Overview
Purpose
We investigated the oncologic effect of palliative transurethral resection of the prostate (pTURP) in patients with prostate cancer who received primary androgen deprivation therapy.
Methods
We reviewed 614 patients, including 83 who underwent pTURP; those with incidental prostate cancer were excluded. Patients were divided into the TURP group and non-TURP group. Propensity score matching was performed for comorbidity, initial prostate-specific antigen (PSA), TNM stage, and Gleason score (GS). The Kaplan–Meier method was used to confirm castration-resistant prostate cancer (CRPC), cancer-specific survival (CSS), and overall survival (OS). Cox regression was performed to confirm factors affecting CSS.
Results
Before matching, the TURP group had a worse TNM stage (
p
< 0.01) and GS (
p
= 0.028) and larger prostate volume (50.1 vs. 39.0 cc,
p
= 0.005) than the non-TURP group. The most common reason for pTURP was acute urinary retention. After matching, the TURP group showed worse outcomes in CRPC (
p
= 0.003), CSS (
p
= 0.003), and OS (
p
= 0.026). In multivariate analysis, factors for predicting CSS were a positive core percent [hazard ratio (HR) 1.015,
p
= 0.0272], GS (10 vs. ≤8; HR 6.716,
p
= 0.0008), and TURP within 3 months after biopsy (HR 2.543,
p
= 0.0482). The resection weight (HR 1.000,
p
= 0.9730), resection time (HR 1.000,
p
= 0.3670), and blood transfusion (HR 0.630,
p
= 0.1860) were not associated with CSS.
Conclusions
The oncologic effect of pTURP as cytoreductive operation seems to be limited. Patients who had to receive pTURP due to cancer-related symptoms, especially early necessity of pTURP (within 3 months after biopsy), showed worse clinical courses; therefore, they should be treated more carefully and actively.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Androgen Antagonists - administration & dosage
/ Biopsy
/ Cytoreduction Surgical Procedures
/ Humans
/ Male
/ Medicine
/ Oncology
/ Original Article – Clinical Oncology
/ Original – Clinical Oncology
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - pathology
/ Prostatic Neoplasms - surgery
/ Prostatic Neoplasms, Castration-Resistant - pathology
/ Prostatic Neoplasms, Castration-Resistant - surgery
/ Survival
