Journal Article

Insights on the Multifunctional Activities of Magnolol

Wu, Longhuo, Shi, Weimei, Huang, Hao, Zhang, Rui, Huang, Xianhua, Chen, Meiling, Chen, Zhixi, Zhang, Jianhong

2019

Overview

Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from Magnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling pathways include, but are not limited to, NF-κB/MAPK, Nrf2/HO-1, and PI3K/Akt pathways, which are implicated in the biological functions mediated by magnolol. Thus, magnolol is considered as a promising therapeutic agent for clinic research. However, the low water solubility, the low bioavailability, and the rapid metabolism of magnolol dramatically limit its clinical application. In this review, we will comprehensively discuss the last five-year progress of the biological activities of magnolol, including anti-inflammatory, antimicroorganism, antioxidative, anticancer, neuroprotective, cardiovascular protection, metabolism regulation, and ion-mediating activity.

• Publisher: Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc
• Subject: 1-Phosphatidylinositol 3-kinase / AKT protein / Anti-Inflammatory Agents - analysis / Antineoplastic Agents - analysis / Antioxidants - analysis / Bioavailability / Biphenyl / Biphenyl Compounds - chemistry / Biphenyl Compounds - metabolism / Biphenyl Compounds - pharmacology / Biphenyl Compounds - therapeutic use / Cardiovascular Agents - analysis / Chemical compounds / Drugs, Chinese Herbal - chemistry / Drugs, Chinese Herbal - metabolism / Drugs, Chinese Herbal - pharmacology / Drugs, Chinese Herbal - therapeutic use / Enzymes / Health aspects / Herbal medicine / Humans / Inflammation / Lignans - chemistry / Lignans - metabolism / Lignans - pharmacology / Lignans - therapeutic use / Liver / Magnolia - chemistry / MAP kinase / MAP Kinase Signaling System - drug effects / Medicine, Chinese Traditional / Metabolism / Metabolites / Motility / Neuroprotection / Neuroprotective Agents - analysis / NF-E2-Related Factor 2 - drug effects / NF-E2-Related Factor 2 - metabolism / NF-kappa B - drug effects / NF-kappa B - metabolism / NF-κB protein / Pharmacology / Phosphatidylinositol 3-Kinases - drug effects / Phosphatidylinositol 3-Kinases - metabolism / Physiological aspects / Povidone / Review / Signal Transduction - drug effects / Toxicology / Traditional Chinese medicine