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![Human FOXP3 and cancer](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
Human FOXP3 and cancer
by
GHIRINGHELLI, F
, MIGNOT, G
, LADOIRE, S
, APETOH, L
, MARTIN, F
in
Biological and medical sciences
/ Cancer
/ Cell physiology
/ Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
/ Cellular biology
/ DNA Damage
/ Epigenesis, Genetic
/ Forkhead Transcription Factors - analysis
/ Forkhead Transcription Factors - chemistry
/ Forkhead Transcription Factors - genetics
/ Forkhead Transcription Factors - physiology
/ Foxp3 protein
/ Fundamental and applied biological sciences. Psychology
/ Gene deletion
/ Gene Expression Regulation
/ Genes, Tumor Suppressor
/ Genetic aspects
/ Genetics
/ Humans
/ Immunology
/ Immunoregulation
/ Lymphocytes
/ Lymphocytes T
/ Molecular and cellular biology
/ Neoplasms - etiology
/ Neoplasms - genetics
/ Neoplasms - immunology
/ Neoplasms - therapy
/ Oncology
/ Physiological aspects
/ Prognosis
/ Risk factors
/ T cells
/ T-cell receptor
/ T-Lymphocytes, Regulatory - immunology
/ T-Lymphocytes, Regulatory - metabolism
/ Transcription factors
/ Tumor cells
/ Tumor suppressor genes
2010
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Human FOXP3 and cancer
by
GHIRINGHELLI, F
, MIGNOT, G
, LADOIRE, S
, APETOH, L
, MARTIN, F
in
Biological and medical sciences
/ Cancer
/ Cell physiology
/ Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
/ Cellular biology
/ DNA Damage
/ Epigenesis, Genetic
/ Forkhead Transcription Factors - analysis
/ Forkhead Transcription Factors - chemistry
/ Forkhead Transcription Factors - genetics
/ Forkhead Transcription Factors - physiology
/ Foxp3 protein
/ Fundamental and applied biological sciences. Psychology
/ Gene deletion
/ Gene Expression Regulation
/ Genes, Tumor Suppressor
/ Genetic aspects
/ Genetics
/ Humans
/ Immunology
/ Immunoregulation
/ Lymphocytes
/ Lymphocytes T
/ Molecular and cellular biology
/ Neoplasms - etiology
/ Neoplasms - genetics
/ Neoplasms - immunology
/ Neoplasms - therapy
/ Oncology
/ Physiological aspects
/ Prognosis
/ Risk factors
/ T cells
/ T-cell receptor
/ T-Lymphocytes, Regulatory - immunology
/ T-Lymphocytes, Regulatory - metabolism
/ Transcription factors
/ Tumor cells
/ Tumor suppressor genes
2010
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![Human FOXP3 and cancer](https://www.mbrl.ae/o/mbrl-theme/images/site-assets/generic/no-book-image.png)
Human FOXP3 and cancer
by
GHIRINGHELLI, F
, MIGNOT, G
, LADOIRE, S
, APETOH, L
, MARTIN, F
in
Biological and medical sciences
/ Cancer
/ Cell physiology
/ Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
/ Cellular biology
/ DNA Damage
/ Epigenesis, Genetic
/ Forkhead Transcription Factors - analysis
/ Forkhead Transcription Factors - chemistry
/ Forkhead Transcription Factors - genetics
/ Forkhead Transcription Factors - physiology
/ Foxp3 protein
/ Fundamental and applied biological sciences. Psychology
/ Gene deletion
/ Gene Expression Regulation
/ Genes, Tumor Suppressor
/ Genetic aspects
/ Genetics
/ Humans
/ Immunology
/ Immunoregulation
/ Lymphocytes
/ Lymphocytes T
/ Molecular and cellular biology
/ Neoplasms - etiology
/ Neoplasms - genetics
/ Neoplasms - immunology
/ Neoplasms - therapy
/ Oncology
/ Physiological aspects
/ Prognosis
/ Risk factors
/ T cells
/ T-cell receptor
/ T-Lymphocytes, Regulatory - immunology
/ T-Lymphocytes, Regulatory - metabolism
/ Transcription factors
/ Tumor cells
/ Tumor suppressor genes
2010
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![Human FOXP3 and cancer](https://syndetics.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=MBRL&type=mbrl)
Journal Article
Human FOXP3 and cancer
2010
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Overview
FOXP3 is a transcription factor necessary and sufficient for induction of the immunosuppressive functions in regulatory T lymphocytes. Its expression was first considered as specific of this cell type, but FOXP3 can also be transiently expressed in T-cell antigen receptor-activated human nonregulatory T cells. Recent data indicate that FOXP3 is also expressed by some nonlymphoid cells, in which it can repress various oncogenes that are restored following FOXP3 deletion or mutation. This review summarizes major advances in (1) the understanding of Foxp3 functions in human regulatory T cells, (2) the prognostic significance of Foxp3-expressing T cells in human malignancies and (3) the significance of Foxp3 expression in human tumor cells.
Publisher
Nature Publishing Group
Subject
Biological and medical sciences
/ Cancer
/ Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
/ Forkhead Transcription Factors - analysis
/ Forkhead Transcription Factors - chemistry
/ Forkhead Transcription Factors - genetics
/ Forkhead Transcription Factors - physiology
/ Fundamental and applied biological sciences. Psychology
/ Genetics
/ Humans
/ Molecular and cellular biology
/ Oncology
/ T cells
/ T-Lymphocytes, Regulatory - immunology
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