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Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China
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Journal Article
Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China
2023
Overview
Osteoporosis (OP) is a common metabolic bone disease characterized by loss of bone mass.
is considered to be a powerful immune and inflammatory suppressor. This study aimed to assess association between genetic loci in
and susceptibility to OP.
Association analysis between
genetic loci and OP risk through SNPStats online software. FPRP analysis (false-positive report probability) verified whether the positive results were noteworthy findings. Linkage disequilibrium (LD) and haplotype analysis were completed by Haploview 4.2 and SNPStats. Multi-factor dimensionality reduction (MDR) was used to assess interaction of SNP-SNP in susceptibility to OP.
Allele \"G\" of
-rs1554286 (OR = 1.21, p = 0.013), allele \"C\" of
-rs1518111 (OR = 1.22,
= 0.011), allele \"C\" of
-rs3024490 (OR = 1.20,
= 0.018), and allele \"G\" of
-rs1800871 (OR = 1.21,
= 0.015) were risk factors for OP. In females, smoking, drinking, or aging ≤60 years old participants, the above genetic loci are also significantly associated with the increased risk of OP. FPRP analysis showed that all positive results are noteworthy findings. There are significant differences in serum levels of uric acid, mean hemoglobin concentration, or mean hemoglobin among different genotypes of
gene loci. MDR showed that four loci model composed rs1554286, rs1518111, rs3021094, and rs1800871 is the best model for predicting OP risk.
-rs1554286, -rs1518111, -rs3021094, and -rs1800871 are risk factors for susceptibility to OP.
Publisher
Dove Medical Press Limited,Taylor & Francis Ltd,Dove,Dove Medical Press
