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The mucosal immune system: master regulator of bidirectional gut–brain communications
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Journal Article
The mucosal immune system: master regulator of bidirectional gut–brain communications
2017
Overview
Key Points
Common gastrointestinal diseases, such as IBS, functional dyspepsia and IBD, are closely linked to psychological morbidity
This link is driven in part through bidirectional signalling between the brain and gut, which reciprocally regulate each other
Growing evidence implicates the importance of immune activation, which might be overt (IBD) or more subtle (IBS, functional dyspepsia) in pathological gut–brain interactions
The composition of the intestinal microbiota affects behaviour and mood, which could in part rely on selective activation of distinct host cytokine responses
Therapeutic targeting of gut microorganisms, host immunity or psychological symptoms could hold the key to uncoupling pathological interactions between the gut and brain
Bidirectional gut–brain communications are proving key to both gastrointestinal and neurological diseases. This Review explores the role of the mucosal immune system as gatekeeper and master regulator of these brain–gut and gut–brain communications.
Communication between the brain and gut is not one-way, but a bidirectional highway whereby reciprocal signals between the two organ systems are exchanged to coordinate function. The messengers of this complex dialogue include neural, metabolic, endocrine and immune mediators responsive to diverse environmental cues, including nutrients and components of the intestinal microbiota (microbiota–gut–brain axis). We are now starting to understand how perturbation of these systems affects transition between health and disease. The pathological repercussions of disordered gut–brain dialogue are probably especially pertinent in functional gastrointestinal diseases, including IBS and functional dyspepsia. New insights into these pathways might lead to novel treatment strategies in these common gastrointestinal diseases. In this Review, we consider the role of the immune system as the gatekeeper and master regulator of brain–gut and gut–brain communications. Although adaptive immunity (T cells in particular) participates in this process, there is an emerging role for cells of the innate immune compartment (including innate lymphoid cells and cells of the mononuclear phagocyte system). We will also consider how these key immune cells interact with the specific components of the enteric and central nervous systems, and rapidly respond to environmental variables, including the microbiota, to alter gut homeostasis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Enteric Nervous System - immunology
/ Enteric Nervous System - microbiology
/ Enteric Nervous System - physiology
/ Gastrointestinal Diseases - immunology
/ Gastrointestinal Diseases - microbiology
/ Gastrointestinal Diseases - physiopathology
/ Gastrointestinal Diseases - psychology
/ Gastrointestinal Microbiome - physiology
/ Humans
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - microbiology
/ Intestinal Mucosa - physiology
/ Microbiota (Symbiotic organisms)
/ Signal Transduction - physiology
/ T cells
