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AACR Annual Meeting 2021
by
Reeves, Cheryl
in
Cancer
/ Chemotherapy
/ Cholangiocarcinoma
/ Fibroblast growth factor receptor 2
/ Glioma
/ Hematology, Oncology, and Palliative Medicine
/ Lung cancer
/ Melanoma
/ Neutropenia
/ Neutrophils
/ Non-small cell lung carcinoma
/ Platinum
/ Response rates
2021
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AACR Annual Meeting 2021
by
Reeves, Cheryl
in
Cancer
/ Chemotherapy
/ Cholangiocarcinoma
/ Fibroblast growth factor receptor 2
/ Glioma
/ Hematology, Oncology, and Palliative Medicine
/ Lung cancer
/ Melanoma
/ Neutropenia
/ Neutrophils
/ Non-small cell lung carcinoma
/ Platinum
/ Response rates
2021
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Do you wish to request the book?
AACR Annual Meeting 2021
by
Reeves, Cheryl
in
Cancer
/ Chemotherapy
/ Cholangiocarcinoma
/ Fibroblast growth factor receptor 2
/ Glioma
/ Hematology, Oncology, and Palliative Medicine
/ Lung cancer
/ Melanoma
/ Neutropenia
/ Neutrophils
/ Non-small cell lung carcinoma
/ Platinum
/ Response rates
2021
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Journal Article
AACR Annual Meeting 2021
2021
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Overview
The results showed a significant improvement in the pathological complete response (co-primary endpoint) in patients with resectable NSCLC treated with neoadjuvant nivolumab (360 mg; n=179) plus platinum-doublet chemotherapy every 3 weeks (24·0%) versus chemotherapy alone (n=179; 2·2%; odds ratio 13·94, 99% CI 3·49–55·75; p<0·0001). Lipika Goyal (Massachusetts General Hospital Cancer Center, Boston, MA, USA) showed that this study met the primary endpoint with an objective response rate of 41·7% (43/103; 95% CI 32·1–51·9) for patients with intrahepatic cholangiocarcinoma with FGFR2 fusions or rearrangements. Dabrafenib plus trametinib in high and low grade glioma Vivek Subbiah (MD Anderson Cancer Center, Houston, TX, USA) presented the results from a non-randomised, open-label, phase 2 study of oral dabrafenib (150 mg twice daily) plus oral trametinib (2 mg once daily) in adult patients with BRAFV600E mutation-positive high-grade or low-grade glioma.
Publisher
Elsevier Ltd,Elsevier Limited
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