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Prospective evaluation of risk-appropriate management of uveal melanoma patients informed by gene expression profiling

by Oliver, Scott C N , Schefler, Amy C , Firestone, Brian , Daniels, Anthony B , Skalet, Alison , Mason, John , Alsina, Katherina M , Plasseraud, Kristen M , Monzon, Federico A

in DecisionDx-UM / gene expression profiling / imaging / ocular melanoma / Short Communication / surveillance / uveal melanoma

2020

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Prospective evaluation of risk-appropriate management of uveal melanoma patients informed by gene expression profiling

by Oliver, Scott C N , Schefler, Amy C , Firestone, Brian , Daniels, Anthony B , Skalet, Alison , Mason, John , Alsina, Katherina M , Plasseraud, Kristen M , Monzon, Federico A

in DecisionDx-UM / gene expression profiling / imaging / ocular melanoma / Short Communication / surveillance / uveal melanoma

2020

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Prospective evaluation of risk-appropriate management of uveal melanoma patients informed by gene expression profiling

by Oliver, Scott C N , Schefler, Amy C , Firestone, Brian , Daniels, Anthony B , Skalet, Alison , Mason, John , Alsina, Katherina M , Plasseraud, Kristen M , Monzon, Federico A

in DecisionDx-UM / gene expression profiling / imaging / ocular melanoma / Short Communication / surveillance / uveal melanoma

2020

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Journal Article

Prospective evaluation of risk-appropriate management of uveal melanoma patients informed by gene expression profiling

Oliver, Scott C N,

Schefler, Amy C,

Firestone, Brian,

Daniels, Anthony B,

Skalet, Alison,

Mason, John,

Alsina, Katherina M,

Plasseraud, Kristen M,

Monzon, Federico A

2020

Overview

The Clinical Application of DecisionDx-UM Gene Expression Assay Results study aimed to evaluate the clinical utility of the prognostic 15-gene expression profile (15-GEP) test for uveal melanoma (UM) patients in a large, prospective multicenter cohort. Nine centers prospectively enrolled 138 UM patients clinically tested with the 15-GEP. Physician-recommended specialty referrals and metastatic surveillance regimens were collected. A total of 93% of high-risk class 2 patients were referred to medical oncology for follow-up, compared with 51% of class 1 patients. A majority (62%) of class 2 patients were recommended overall high-intensity metastatic surveillance, while 85% of class 1 patients were recommended low-intensity metastatic surveillance. Treatment plan recommendations for UM patients are aligned with GEP-informed metastatic risk, consistent with prior studies.

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Publisher

Future Medicine Ltd,Taylor & Francis Group

Subject

DecisionDx-UM

/ gene expression profiling

/ imaging

/ ocular melanoma

/ Short Communication

/ surveillance

/ uveal melanoma