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A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery
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A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery
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Journal Article
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery
2006
Overview
A quality-control system surveys the lumen of the endoplasmic reticulum for terminally misfolded proteins. Polypeptides singled out by this system are ultimately degraded by the cytosolic ubiquitin-proteasome pathway. Key components of both the endoplasmic reticulum quality-control system and the degradation machinery have been identified, but a connection between the two systems has remained elusive. Here, we report an association between the endoplasmic reticulum quality-control lectin Yos9p and Hrd3p, a component of the ubiquitin-proteasome system that links these pathways. We identify designated regions in the luminal domain of Hrd3p that interact with Yos9p and the ubiquitin ligase Hrd1p. Binding of misfolded proteins occurs through Hrd3p, suggesting that Hrd3p recognises proteins that deviate from their native conformation, whereas Yos9p ensures that only terminally misfolded polypeptides are degraded.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Carrier Proteins - chemistry
/ Carrier Proteins - metabolism
/ Endoplasmic Reticulum - metabolism
/ Lectins
/ letter
/ Ligases
/ Membrane Glycoproteins - chemistry
/ Membrane Glycoproteins - genetics
/ Membrane Glycoproteins - metabolism
/ Proteins
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae - metabolism
/ Saccharomyces cerevisiae Proteins - chemistry
/ Saccharomyces cerevisiae Proteins - genetics
/ Saccharomyces cerevisiae Proteins - metabolism
/ Ubiquitin-Protein Ligases - chemistry
