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CD57 in human natural killer cells and T-lymphocytes
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Journal Article
CD57 in human natural killer cells and T-lymphocytes
2016
Overview
The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated ‘senescent’ cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease and discuss how this marker can inform researchers about their likely functions in human blood and tissues in vivo. While CD57 expression on human lymphocytes indicates an inability to proliferate, these cells also display high cytotoxic potential, and CD57
pos
NK cells exhibit both memory-like features and potent effector functions. Accordingly, frequencies of CD57-expressing cells in blood and tissues have been correlated with clinical prognosis in chronic infections or various cancers and with human aging. Functional modulation of senescent CD57
pos
T-cells and mature CD57
pos
NK cells may therefore represent innovative strategies for protection against human immunological aging and/or various chronic diseases.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Antigens
/ Autoimmune Diseases - immunology
/ Autoimmune Diseases - metabolism
/ Cancer
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - metabolism
/ Cell Differentiation - immunology
/ Cytotoxicity, Immunologic - immunology
/ Humans
/ Killer Cells, Natural - immunology
/ Killer Cells, Natural - metabolism
/ Medicine
/ Oncology
/ Proteins
