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Limitations of plasmid vaccines to complex viruses: selected myxoma virus antigens as DNA vaccines were not protective
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Limitations of plasmid vaccines to complex viruses: selected myxoma virus antigens as DNA vaccines were not protective
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Journal Article
Limitations of plasmid vaccines to complex viruses: selected myxoma virus antigens as DNA vaccines were not protective
2004
Overview
Myxoma virus, a poxvirus of the genus
Leporipoxvirus, is the causative agent of the disease myxomatosis which is highly lethal in European rabbits (
Oryctolagus cuniculus). Current vaccines to protect against myxomatosis are either attenuated live strains of the virus or the antigenically related rabbit fibroma virus. We examined the immune response of outbred domestic rabbits to the individual myxoma virus antigens M055R, M073R, M115L and M121R, delivered as DNA vaccines co-expressing rabbit interleukin-2 or interleukin-4. M115L and M121R were also delivered simultaneously. None of the vaccine constructs were able to protect the rabbits from disease or reduce mortality after challenge with virulent myxoma virus, despite induction of antigen-specific cell-mediated and humoral immune responses.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Biological and medical sciences
/ DNA
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Plasmids
/ Poxviridae Infections - prevention & control
/ Poxvirus
/ Rabbit
/ Rabbits
/ Tumor Virus Infections - prevention & control
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
/ Vaccines, DNA - administration & dosage
/ Viral Vaccines - administration & dosage
/ Virology
